Michael Trauner received his medical education at the Karl Franzens University School of Medicine in Graz, where he started his residency and fellowship in Internal Medicine in 1991. From 1994-1997 he was trained Erwin Schroedinger Postdoctoral Research Fellow of the Austrian Science Foundation at the Department of Internal Medicine (Section of Digestive Diseases) and Liver Center at the Yale University, USA (Prof. James L. Boyer) where he worked on the molecular alterations of hepatobiliry transport systems in cholestasis. After returning to Graz he completed his training in Internal Medicine and Fellowship in Gastroenterology and Hepatology in Graz and established an internationally recognized research goup in cholestatic and fatty liver diseases and founded the Liver Center. His main research interests are the molecular regulation of hepatobiliary ABC transporters in cholestatic and fatty liver diseases by nuclear receptors, mechanisms of cell injury in cholestatic and fatty liver disease and pharmacological treatment of cholestatic and fatty liver diseases. In 2000 he was promoted to Associate Professor of Medicine (Tenure Track) and 2005 Full Professor of Medicine, Experimental and Clinical Hepatology at the Medical University of Graz. Since 2010 he is Professor and Chair of Gastroenterology and Hepatology at the Medical University of Vienna where he is also Division Head of one of the largest clinical Gastroenterology, Endoscopy and Liver services in Europe. He has published more than 230 peer reviewed scientific papers, mainly on molecular and clinical aspects of cholestatic and metabolic liver diseases, and is corresponding member of the Austrian Academy of Sciences and several other national and international professional and scientific societies. He has also served on several Editorial Boards and Scientific Committees such as EASL Governing Board Member (2006-2010), Council Member of United European Gastroenterology (since 2010), Associate Editor of the Journal of Hepatology (2004-2009) and Hepatology (since 2011).
Mike White began his career at Amersham International (1985 - 1995) in the areas of molecular biology products and technologies for studies of gene function. While working at Amersham, he was awarded a PhD from Imperial College London. During this period he pioneered the use of the firefly luciferase gene as a reporter, particularly for non-invasive imaging in mammalian cells. In 1995, he was appointed to a lectureship at Liverpool University and to Professor at the beginning of 2004. At Liverpool, he founded the Centre for Cell Imaging (CCI), a suite of microscopy and imaging equipment, specifically designed for the non-invasive imaging of cellular processes.
In 2010 Mike moved to Manchester University and established the Systems Microscopy Centre. The SMC incorporates state-of-the-art equipment for multi-photon and confocal microscopy plus high throughput luminescence and fluorescence imaging. The major overall interest of White's group is to understand the relationship between signalling dynamics in specifying transcriptional control and cell fate.
Mike’s group have worked on the dynamics and function of the NF-κB signalling system for about 10 years. In 2004, his group published a paper in Science that demonstrated that the NF-κB can oscillate between the cytoplasm and the nucleus of cells following stimulation. They suggested that the timing of these oscillations may regulate downstream gene expression. This was a new way of thinking about how NF-κB may control gene expression. In subsequent papers they provided evidence that the timing of pulses of cytokine (TNFα) stimulation can drive oscillations at different frequencies and that this alters the pattern of gene expression. The group have increasingly used mathematical models of the NF-κB system to provide testable predictions about the function and dynamics of NF-κB signalling.
Recent work has been funded through a £6m BBSRC SABR project between Manchester, Liverpool and Warwick. The project was started in April 2008 and involves a multidisciplinary team of researchers. The work includes cell imaging, image analysis, gene expression analysis, bioinformatics, proteomics and phosphor-proteomics as well as model-led data analysis, and mathematical modelling and simulation. Mike has also collaborated with Prof. Julian Davis for 13 years on the dynamics of pituitary hormone gene expression. Major discoveries have included the observation that prolactin transcription is extremely stochastic. This has been achieved using single cell fluorescent and luminescent imaging of single cells (both cell lines and primary cells).
In addition to basic research activity, Mike has extensive collaborations with industry (e.g. Hamamatsu & Zeiss) & has played a role in developing tools for public engagement science. In 2006 he led a multidisciplinary group that presented at the Royal Society Summer & Glasgow exhibitions & at Science Day at Buckingham Palace.